Drug interactions
Orlistat + Oxcarbazepine
Severity: Moderate
Orlistat and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat has been associated with reduced antiepileptic exposure and breakthrough seizures in case reports. Reduced oxcarbazepine absorption is plausible, though data specific to this drug are limited.
What this interaction means in plain words
Orlistat and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orlistat belongs to Miscellaneous; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Orlistat may reduce absorption of lipophilic drugs by decreasing fat digestion; a precise mechanism for oxcarbazepine is unconfirmed.
What to do
Monitor seizure control and consider checking oxcarbazepine metabolite levels when orlistat is started. Consider avoiding orlistat in patients with poorly controlled epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Frequently asked questions
Can I take Orlistat with Oxcarbazepine?
MediHelp rates the interaction as moderate. Orlistat and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat has been associated with reduced antiepileptic exposure and breakthrough seizures in case reports. Reduced oxcarbazepine absorption is plausible, though data specific to this drug are limited.
How serious is the interaction between Orlistat and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and consider checking oxcarbazepine metabolite levels when orlistat is started. Consider avoiding orlistat in patients with poorly controlled epilepsy.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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