Drug interactions
Orlistat + Primidone
Severity: Moderate
Orlistat and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat has been associated with reduced anticonvulsant effect and seizures in patients on antiepileptics. No primidone-specific data exist, so risk is extrapolated.
What this interaction means in plain words
Orlistat and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orlistat belongs to Miscellaneous; Primidone belongs to Central Nervous System.
Why it happens
Possible decreased oral absorption caused by orlistat's fat malabsorption; not established for primidone.
What to do
Monitor seizure control and primidone and phenobarbital levels when orlistat is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Orlistat with Primidone?
MediHelp rates the interaction as moderate. Orlistat and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat has been associated with reduced anticonvulsant effect and seizures in patients on antiepileptics. No primidone-specific data exist, so risk is extrapolated.
How serious is the interaction between Orlistat and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and primidone and phenobarbital levels when orlistat is started or stopped.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporine, Cyclosporin, Triheptanoin. The full list is on the Orlistat page.
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