Drug interactions
Orphenadrin + Papaveretum
Severity: Major
Orphenadrin and Papaveretum: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids, including morphine, and adds opioid CNS and respiratory depression to the sedating effect of orphenadrine. Excessive sedation and breathing depression are possible.
What this interaction means in plain words
Orphenadrin and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with additive antimuscarinic effects on the gut and bladder.
What to do
Start with reduced opioid doses and monitor sedation and respiratory rate. Avoid the combination in patients with respiratory compromise.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Orphenadrin
Frequently asked questions
Can I take Orphenadrin with Papaveretum?
MediHelp rates the interaction as major. Orphenadrin and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids, including morphine, and adds opioid CNS and respiratory depression to the sedating effect of orphenadrine. Excessive sedation and breathing depression are possible.
How serious is the interaction between Orphenadrin and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced opioid doses and monitor sedation and respiratory rate. Avoid the combination in patients with respiratory compromise.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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