Drug interactions
Orphenadrin + Triazolam
Severity: Moderate
Orphenadrin and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine can add to the sedative and psychomotor-impairing effects of triazolam. This raises the risk of daytime drowsiness, confusion, ataxia and falls.
What this interaction means in plain words
Orphenadrin and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic synergy.
What to do
Use the lowest effective doses and counsel patients on avoiding driving or hazardous tasks. Monitor older patients closely for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Frequently asked questions
Can I take Orphenadrin with Triazolam?
MediHelp rates the interaction as moderate. Orphenadrin and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine can add to the sedative and psychomotor-impairing effects of triazolam. This raises the risk of daytime drowsiness, confusion, ataxia and falls.
How serious is the interaction between Orphenadrin and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients on avoiding driving or hazardous tasks. Monitor older patients closely for oversedation.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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