Drug interactions
Orphenadrin + Triclofos
Severity: Moderate
Orphenadrin and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic whose active metabolite depresses the central nervous system, and orphenadrine adds to this effect. Excessive sedation, dizziness and confusion may result.
What this interaction means in plain words
Orphenadrin and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic synergy.
What to do
Monitor for excessive sedation and reduce the dose of the hypnotic if needed. Avoid combining in older patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Frequently asked questions
Can I take Orphenadrin with Triclofos?
MediHelp rates the interaction as moderate. Orphenadrin and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic whose active metabolite depresses the central nervous system, and orphenadrine adds to this effect. Excessive sedation, dizziness and confusion may result.
How serious is the interaction between Orphenadrin and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the dose of the hypnotic if needed. Avoid combining in older patients where possible.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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