Drug interactions
Orphenadrine + Oxymorphone
Severity: Moderate
Orphenadrine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness and dizziness, and it adds to opioid sedation and impaired psychomotor performance. Anticholinergic effects such as constipation and urinary retention may also be worsened.
What this interaction means in plain words
Orphenadrine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive anticholinergic effects with opioid-induced gut and bladder slowing.
What to do
Monitor for oversedation, confusion, constipation and urinary retention, and use the lowest effective doses. Avoid in elderly patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Orphenadrine with Oxymorphone?
MediHelp rates the interaction as moderate. Orphenadrine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness and dizziness, and it adds to opioid sedation and impaired psychomotor performance. Anticholinergic effects such as constipation and urinary retention may also be worsened.
How serious is the interaction between Orphenadrine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion, constipation and urinary retention, and use the lowest effective doses. Avoid in elderly patients where possible.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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