Drug interactions
Orphenadrine + Thioridazine
Severity: Moderate
Orphenadrine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic and sedating properties, so together they can cause marked drowsiness, confusion, dry mouth, urinary retention and constipation. Elderly patients are especially vulnerable to delirium and falls.
What this interaction means in plain words
Orphenadrine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic and central nervous system depressant effects.
What to do
Monitor for sedation and anticholinergic toxicity and use the lowest effective doses. Consider an alternative muscle relaxant in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Orphenadrine with Thioridazine?
MediHelp rates the interaction as moderate. Orphenadrine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic and sedating properties, so together they can cause marked drowsiness, confusion, dry mouth, urinary retention and constipation. Elderly patients are especially vulnerable to delirium and falls.
How serious is the interaction between Orphenadrine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic toxicity and use the lowest effective doses. Consider an alternative muscle relaxant in older patients.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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