Drug interactions
Orphenadrine + Tiotropium
Severity: Moderate
Orphenadrine and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has strong anticholinergic activity and adds to the antimuscarinic effects of tiotropium. Patients may develop dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
What this interaction means in plain words
Orphenadrine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid the combination in older patients and those with glaucoma or urinary retention. Otherwise monitor for anticholinergic toxicity and use the lowest effective orphenadrine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Frequently asked questions
Can I take Orphenadrine with Tiotropium?
MediHelp rates the interaction as moderate. Orphenadrine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has strong anticholinergic activity and adds to the antimuscarinic effects of tiotropium. Patients may develop dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
How serious is the interaction between Orphenadrine and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients and those with glaucoma or urinary retention. Otherwise monitor for anticholinergic toxicity and use the lowest effective orphenadrine dose.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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