Drug interactions
Orphenadrine + Ziprasidone
Severity: Moderate
Orphenadrine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a muscle relaxant with anticholinergic and sedative properties, and it can add to ziprasidone-related drowsiness, confusion and anticholinergic effects. Older adults are especially vulnerable.
What this interaction means in plain words
Orphenadrine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for sedation, confusion, urinary retention and constipation. Reduce the dose or choose another muscle relaxant if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Orphenadrine with Ziprasidone?
MediHelp rates the interaction as moderate. Orphenadrine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is a muscle relaxant with anticholinergic and sedative properties, and it can add to ziprasidone-related drowsiness, confusion and anticholinergic effects. Older adults are especially vulnerable.
How serious is the interaction between Orphenadrine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion, urinary retention and constipation. Reduce the dose or choose another muscle relaxant if effects are troublesome.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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