Drug interactions
Oxandrolone + Tolazamide
Severity: Moderate
Oxandrolone and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anabolic steroids can improve insulin sensitivity and lower blood glucose, which may increase the hypoglycemic effect of sulfonylureas. Hypoglycemia has been described with this class combined with antidiabetic agents.
What this interaction means in plain words
Oxandrolone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anabolic androgens increase insulin sensitivity and glucose tolerance, adding to sulfonylurea action.
What to do
Monitor blood glucose closely when oxandrolone is started, and reduce the tolazamide dose if glucose falls. Re-check glucose when oxandrolone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Oxandrolone with Tolazamide?
MediHelp rates the interaction as moderate. Oxandrolone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anabolic steroids can improve insulin sensitivity and lower blood glucose, which may increase the hypoglycemic effect of sulfonylureas. Hypoglycemia has been described with this class combined with antidiabetic agents.
How serious is the interaction between Oxandrolone and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when oxandrolone is started, and reduce the tolazamide dose if glucose falls. Re-check glucose when oxandrolone is stopped.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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