Drug interactions
Oxandrolone + Warfarin
Severity: Major
Oxandrolone and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxandrolone markedly increases sensitivity to warfarin, with INR elevations and bleeding documented, sometimes at low oxandrolone doses.
What this interaction means in plain words
Oxandrolone and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Anabolic steroid alters clotting factor synthesis and catabolism and may reduce warfarin clearance.
What to do
Check INR frequently when oxandrolone is started, changed or stopped, and reduce warfarin dose, often substantially. Monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Oxandrolone with Warfarin?
MediHelp rates the interaction as major. Oxandrolone and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxandrolone markedly increases sensitivity to warfarin, with INR elevations and bleeding documented, sometimes at low oxandrolone doses.
How serious is the interaction between Oxandrolone and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR frequently when oxandrolone is started, changed or stopped, and reduce warfarin dose, often substantially. Monitor for bleeding.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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