Drug interactions
Oxaprozin + Phenindione
Severity: Major
Oxaprozin and Phenindione: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is a vitamin K antagonist, and oxaprozin inhibits platelet aggregation and can cause gastrointestinal ulceration. Together they markedly increase the risk of serious bleeding.
What this interaction means in plain words
Oxaprozin and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment from vitamin K antagonism and NSAID platelet inhibition and mucosal injury; NSAID protein-binding displacement may also contribute.
What to do
Avoid the combination and use paracetamol if analgesia is needed. If it cannot be avoided, monitor INR closely and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Phenindione?
MediHelp rates the interaction as major. Oxaprozin and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is a vitamin K antagonist, and oxaprozin inhibits platelet aggregation and can cause gastrointestinal ulceration. Together they markedly increase the risk of serious bleeding.
How serious is the interaction between Oxaprozin and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use paracetamol if analgesia is needed. If it cannot be avoided, monitor INR closely and consider gastroprotection.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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