Drug interactions
Oxaprozin + Phenoxybenzamine
Severity: Minor
Oxaprozin and Phenoxybenzamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine is an alpha-blocker used for vasodilation, and NSAIDs may theoretically reduce vasodilatory prostaglandins. Clinically significant loss of effect has not been well documented.
What this interaction means in plain words
Oxaprozin and Phenoxybenzamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic antagonism via reduced prostaglandin-mediated vasodilation.
What to do
No dose change is required. Monitor blood pressure if the NSAID is used for an extended period.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Phenoxybenzamine?
MediHelp rates the interaction as minor. Oxaprozin and Phenoxybenzamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenoxybenzamine is an alpha-blocker used for vasodilation, and NSAIDs may theoretically reduce vasodilatory prostaglandins. Clinically significant loss of effect has not been well documented.
How serious is the interaction between Oxaprozin and Phenoxybenzamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor blood pressure if the NSAID is used for an extended period.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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