Drug interactions
Oxaprozin + Propranolol
Severity: Moderate
Oxaprozin and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin may blunt the blood pressure lowering effect of propranolol, especially with sustained use. Hypertension control may worsen.
What this interaction means in plain words
Oxaprozin and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Propranolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandin synthesis and sodium and water retention antagonize beta-blocker effect.
What to do
Monitor blood pressure when starting, changing or stopping oxaprozin and adjust antihypertensive therapy if required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Oxaprozin with Propranolol?
MediHelp rates the interaction as moderate. Oxaprozin and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin may blunt the blood pressure lowering effect of propranolol, especially with sustained use. Hypertension control may worsen.
How serious is the interaction between Oxaprozin and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting, changing or stopping oxaprozin and adjust antihypertensive therapy if required.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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