Drug interactions
Oxaprozin + Quinapril
Severity: Moderate
Oxaprozin and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin can reduce the antihypertensive effect of quinapril. The combination can also impair renal function, particularly in elderly, dehydrated or renally compromised patients, and may raise potassium.
What this interaction means in plain words
Oxaprozin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium after starting the combination and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Quinapril?
MediHelp rates the interaction as moderate. Oxaprozin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin can reduce the antihypertensive effect of quinapril. The combination can also impair renal function, particularly in elderly, dehydrated or renally compromised patients, and may raise potassium.
How serious is the interaction between Oxaprozin and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting the combination and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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