Drug interactions
Oxaprozin + Reteplase
Severity: Major
Oxaprozin and Reteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase is a thrombolytic that substantially increases bleeding risk, and oxaprozin impairs platelet function and can cause gastrointestinal lesions. Their combination raises the risk of serious hemorrhage.
What this interaction means in plain words
Oxaprozin and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects on hemostasis: fibrinolysis from reteplase plus NSAID-induced platelet dysfunction and mucosal injury.
What to do
Avoid giving NSAIDs around thrombolytic therapy where possible and monitor closely for bleeding, including neurologic and gastrointestinal signs. Use non-NSAID analgesia for pain.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Reteplase?
MediHelp rates the interaction as major. Oxaprozin and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reteplase is a thrombolytic that substantially increases bleeding risk, and oxaprozin impairs platelet function and can cause gastrointestinal lesions. Their combination raises the risk of serious hemorrhage.
How serious is the interaction between Oxaprozin and Reteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving NSAIDs around thrombolytic therapy where possible and monitor closely for bleeding, including neurologic and gastrointestinal signs. Use non-NSAID analgesia for pain.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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