Drug interactions
Oxaprozin + Salicylates
Severity: Moderate
Oxaprozin and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining oxaprozin with a salicylate increases the risk of gastrointestinal irritation and bleeding, and may increase renal adverse effects. Salicylates may also lower the exposure to the NSAID without adding therapeutic benefit.
What this interaction means in plain words
Oxaprozin and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of prostaglandin synthesis and platelet function, with possible displacement from protein binding.
What to do
Avoid routine concurrent use of two NSAID-type agents; if combined, monitor for GI bleeding and renal function and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Salicylates?
MediHelp rates the interaction as moderate. Oxaprozin and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining oxaprozin with a salicylate increases the risk of gastrointestinal irritation and bleeding, and may increase renal adverse effects. Salicylates may also lower the exposure to the NSAID without adding therapeutic benefit.
How serious is the interaction between Oxaprozin and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two NSAID-type agents; if combined, monitor for GI bleeding and renal function and consider gastroprotection.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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