Drug interactions
Oxaprozin + Salsalate
Severity: Moderate
Oxaprozin and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate and, combined with oxaprozin, adds to gastrointestinal and renal risk without a clear efficacy gain. Its effect on platelets is weaker than aspirin, but bleeding risk can still be raised.
What this interaction means in plain words
Oxaprozin and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of prostaglandin synthesis, with possible protein binding displacement.
What to do
Avoid combining two anti-inflammatory agents when possible; if used together, monitor for GI bleeding and renal function and consider a proton pump inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Oxaprozin and Salsalate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Salsalate?
MediHelp rates the interaction as moderate. Oxaprozin and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a non-acetylated salicylate and, combined with oxaprozin, adds to gastrointestinal and renal risk without a clear efficacy gain. Its effect on platelets is weaker than aspirin, but bleeding risk can still be raised.
How serious is the interaction between Oxaprozin and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two anti-inflammatory agents when possible; if used together, monitor for GI bleeding and renal function and consider a proton pump inhibitor.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
