Drug interactions
Oxaprozin + Sulfasalazine
Severity: Minor
Oxaprozin and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established pharmacokinetic or clinically significant interaction exists between sulfasalazine and oxaprozin; the two are often used together in inflammatory arthritis. Both can cause some GI upset or rarely renal effects.
What this interaction means in plain words
Oxaprozin and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No clear mechanism; possible overlapping gastrointestinal and renal adverse effects.
What to do
No routine adjustment is needed; monitor for GI symptoms and periodically check renal function and blood counts as for sulfasalazine therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Sulfasalazine?
MediHelp rates the interaction as minor. Oxaprozin and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-established pharmacokinetic or clinically significant interaction exists between sulfasalazine and oxaprozin; the two are often used together in inflammatory arthritis. Both can cause some GI upset or rarely renal effects.
How serious is the interaction between Oxaprozin and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for GI symptoms and periodically check renal function and blood counts as for sulfasalazine therapy.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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