Drug interactions
Oxaprozin + Telmisartan
Severity: Moderate
Oxaprozin and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of angiotensin receptor blockers and together may impair renal function, especially in elderly, volume-depleted or renally impaired patients. Hyperkalemia may also occur.
What this interaction means in plain words
Oxaprozin and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Telmisartan belongs to Cardiovascular.
Why it happens
NSAID blockade of afferent arteriolar vasodilatory prostaglandins combined with ARB efferent dilation reduces glomerular filtration, and prostaglandin inhibition opposes blood pressure lowering.
What to do
Ensure hydration and monitor serum creatinine, potassium and blood pressure, especially at initiation. Avoid prolonged combined use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Oxaprozin with Telmisartan?
MediHelp rates the interaction as moderate. Oxaprozin and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of angiotensin receptor blockers and together may impair renal function, especially in elderly, volume-depleted or renally impaired patients. Hyperkalemia may also occur.
How serious is the interaction between Oxaprozin and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure hydration and monitor serum creatinine, potassium and blood pressure, especially at initiation. Avoid prolonged combined use where possible.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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