Drug interactions
Oxaprozin + Temocillin
Severity: Minor
Oxaprozin and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the renal tubular secretion of penicillins and may compete for protein binding, potentially raising temocillin levels. The clinical effect is usually modest given the wide therapeutic index of penicillins.
What this interaction means in plain words
Oxaprozin and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion and protein binding.
What to do
No routine adjustment is needed; monitor renal function in patients with impaired kidney function receiving both.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Temocillin?
MediHelp rates the interaction as minor. Oxaprozin and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce the renal tubular secretion of penicillins and may compete for protein binding, potentially raising temocillin levels. The clinical effect is usually modest given the wide therapeutic index of penicillins.
How serious is the interaction between Oxaprozin and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function in patients with impaired kidney function receiving both.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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