Drug interactions
Oxaprozin + Tobramycin inhaled
Severity: Moderate
Oxaprozin and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled tobramycin has low systemic absorption but can accumulate in patients with renal impairment, and NSAIDs may further reduce renal function. Together they may add to nephrotoxicity and ototoxicity risk.
What this interaction means in plain words
Oxaprozin and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal perfusion may impair aminoglycoside clearance, adding to aminoglycoside tubular and cochlear toxicity.
What to do
Monitor serum creatinine and tobramycin levels, and consider hearing assessment in patients with renal impairment or prolonged therapy. Prefer a non-NSAID analgesic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Oxaprozin and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled tobramycin has low systemic absorption but can accumulate in patients with renal impairment, and NSAIDs may further reduce renal function. Together they may add to nephrotoxicity and ototoxicity risk.
How serious is the interaction between Oxaprozin and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin levels, and consider hearing assessment in patients with renal impairment or prolonged therapy. Prefer a non-NSAID analgesic when possible.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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