Drug interactions
Oxaprozin + Vorapaxar
Severity: Major
Oxaprozin and Vorapaxar: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is a potent antiplatelet agent, and NSAIDs add platelet inhibition and gastric mucosal injury. The combination increases the risk of clinically important bleeding.
What this interaction means in plain words
Oxaprozin and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antiplatelet effects from PAR-1 antagonism and cyclooxygenase inhibition, plus NSAID mucosal injury.
What to do
Avoid regular NSAID use with vorapaxar where possible; if needed, use the lowest dose for the shortest time with gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Vorapaxar?
MediHelp rates the interaction as major. Oxaprozin and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar is a potent antiplatelet agent, and NSAIDs add platelet inhibition and gastric mucosal injury. The combination increases the risk of clinically important bleeding.
How serious is the interaction between Oxaprozin and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with vorapaxar where possible; if needed, use the lowest dose for the shortest time with gastroprotection and monitor for bleeding.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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