Drug interactions
Oxaprozin + Willow bark
Severity: Moderate
Oxaprozin and Willow bark: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylate, so combined use duplicates NSAID-type effects and may increase GI irritation and bleeding risk. Salicylates may also compete with oxaprozin for renal tubular secretion.
What this interaction means in plain words
Oxaprozin and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic duplication of cyclooxygenase inhibition plus competition for anionic renal tubular secretion.
What to do
Avoid combining willow bark with oxaprozin; if used, monitor for GI bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Oxaprozin with Willow bark?
MediHelp rates the interaction as moderate. Oxaprozin and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Willow bark contains salicin, which is converted to salicylate, so combined use duplicates NSAID-type effects and may increase GI irritation and bleeding risk. Salicylates may also compete with oxaprozin for renal tubular secretion.
How serious is the interaction between Oxaprozin and Willow bark?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining willow bark with oxaprozin; if used, monitor for GI bleeding and renal function.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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