Drug interactions
Oxazepam + Rifabutin
Severity: Minor
Oxazepam and Rifabutin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is an enzyme inducer that may modestly increase the clearance of drugs. Oxazepam is cleared mainly by glucuronidation, so any reduction in its effect is likely small and of limited clinical importance.
What this interaction means in plain words
Oxazepam and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxazepam belongs to Central Nervous System; Rifabutin belongs to Anti Bacterial.
Why it happens
Possible induction of glucuronidation (UGT) by rifabutin, which is not firmly established for oxazepam.
What to do
No routine adjustment is needed; watch for reduced anxiolytic or hypnotic effect and increase the oxazepam dose only if clinically required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Oxazepam with Rifabutin?
MediHelp rates the interaction as minor. Oxazepam and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifabutin is an enzyme inducer that may modestly increase the clearance of drugs. Oxazepam is cleared mainly by glucuronidation, so any reduction in its effect is likely small and of limited clinical importance.
How serious is the interaction between Oxazepam and Rifabutin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for reduced anxiolytic or hypnotic effect and increase the oxazepam dose only if clinically required.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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