Drug interactions
Oxazepam + Suvorexant
Severity: Moderate
Oxazepam and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents promote sedation, so combined use increases the risk of daytime drowsiness, impaired coordination and slowed reaction times. Older patients are at particular risk of falls.
What this interaction means in plain words
Oxazepam and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxazepam belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A modulation and orexin receptor antagonism.
What to do
Avoid concurrent hypnotic therapy where possible; otherwise use the lowest effective doses and monitor for next-day impairment, adjusting suvorexant down if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Oxazepam and Suvorexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Oxazepam with Suvorexant?
MediHelp rates the interaction as moderate. Oxazepam and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents promote sedation, so combined use increases the risk of daytime drowsiness, impaired coordination and slowed reaction times. Older patients are at particular risk of falls.
How serious is the interaction between Oxazepam and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent hypnotic therapy where possible; otherwise use the lowest effective doses and monitor for next-day impairment, adjusting suvorexant down if needed.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
