Drug interactions
Oxcarbazepine + Pimavanserin
Severity: Moderate
Oxcarbazepine and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce pimavanserin exposure and lead to loss of antipsychotic effect. Labeling suggests dose increase may be needed with strong CYP3A4 inducers.
What this interaction means in plain words
Oxcarbazepine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Pimavanserin belongs to Central Nervous System.
Why it happens
Oxcarbazepine induces CYP3A4, increasing pimavanserin clearance.
What to do
Monitor for reduced efficacy and increase the pimavanserin dose if needed. Avoid the combination if an alternative anticonvulsant is possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Oxcarbazepine with Pimavanserin?
MediHelp rates the interaction as moderate. Oxcarbazepine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce pimavanserin exposure and lead to loss of antipsychotic effect. Labeling suggests dose increase may be needed with strong CYP3A4 inducers.
How serious is the interaction between Oxcarbazepine and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy and increase the pimavanserin dose if needed. Avoid the combination if an alternative anticonvulsant is possible.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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