Drug interactions
Oxcarbazepine + Quinine
Severity: Minor
Oxcarbazepine and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak CYP3A4 inducer and may reduce quinine levels somewhat, which could lessen antimalarial efficacy.
What this interaction means in plain words
Oxcarbazepine and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxcarbazepine belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Why it happens
Weak induction of CYP3A4 by oxcarbazepine, increasing quinine metabolism.
What to do
Monitor clinical response to quinine and consider alternative antimalarial therapy if response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Quinine?
MediHelp rates the interaction as minor. Oxcarbazepine and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxcarbazepine is a weak CYP3A4 inducer and may reduce quinine levels somewhat, which could lessen antimalarial efficacy.
How serious is the interaction between Oxcarbazepine and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to quinine and consider alternative antimalarial therapy if response is poor.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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