Drug interactions
Oxcarbazepine + Sorafenib
Severity: Moderate
Oxcarbazepine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce sorafenib exposure and efficacy. Sorafenib is metabolized in part by CYP3A4 and strong inducers lower its levels.
What this interaction means in plain words
Oxcarbazepine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
CYP3A4 induction by oxcarbazepine increases sorafenib metabolism.
What to do
Prefer a non-inducing antiepileptic and monitor tumor response. Consider dose adjustment if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Oxcarbazepine with Sorafenib?
MediHelp rates the interaction as moderate. Oxcarbazepine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce sorafenib exposure and efficacy. Sorafenib is metabolized in part by CYP3A4 and strong inducers lower its levels.
How serious is the interaction between Oxcarbazepine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiepileptic and monitor tumor response. Consider dose adjustment if efficacy appears reduced.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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