Drug interactions
Oxcarbazepine + Sunitinib
Severity: Moderate
Oxcarbazepine and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce sunitinib and active metabolite concentrations, potentially lowering efficacy. Sunitinib is a CYP3A4 substrate.
What this interaction means in plain words
Oxcarbazepine and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
CYP3A4 induction by oxcarbazepine increases sunitinib clearance.
What to do
Choose a non-inducing anticonvulsant if possible. If combined, monitor response and consider a sunitinib dose increase with tolerability monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Oxcarbazepine with Sunitinib?
MediHelp rates the interaction as moderate. Oxcarbazepine and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce sunitinib and active metabolite concentrations, potentially lowering efficacy. Sunitinib is a CYP3A4 substrate.
How serious is the interaction between Oxcarbazepine and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-inducing anticonvulsant if possible. If combined, monitor response and consider a sunitinib dose increase with tolerability monitoring.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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