Drug interactions
Oxcarbazepine + Tadalafil
Severity: Moderate
Oxcarbazepine and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak to moderate CYP3A4 inducer and may reduce tadalafil concentrations. Reduced efficacy is possible in erectile dysfunction or pulmonary arterial hypertension.
What this interaction means in plain words
Oxcarbazepine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Tadalafil belongs to Genitourinary.
Why it happens
Induction of CYP3A4-mediated tadalafil metabolism by oxcarbazepine.
What to do
Monitor clinical response and adjust the tadalafil dose if needed. In pulmonary hypertension, monitor functional status closely or consider alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Tadalafil?
MediHelp rates the interaction as moderate. Oxcarbazepine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak to moderate CYP3A4 inducer and may reduce tadalafil concentrations. Reduced efficacy is possible in erectile dysfunction or pulmonary arterial hypertension.
How serious is the interaction between Oxcarbazepine and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adjust the tadalafil dose if needed. In pulmonary hypertension, monitor functional status closely or consider alternatives.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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