Drug interactions
Oxcarbazepine + Tolvaptan
Severity: Moderate
Oxcarbazepine and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce tolvaptan exposure by inducing CYP3A4, which can blunt its aquaretic effect. Inadequate response may leave hyponatremia undertreated.
What this interaction means in plain words
Oxcarbazepine and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Tolvaptan belongs to Endocrine.
Why it happens
CYP3A4 induction by oxcarbazepine increases tolvaptan metabolism.
What to do
Monitor serum sodium and clinical response, and increase tolvaptan dose within labeled limits if needed. Note that oxcarbazepine itself can cause hyponatremia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Oxcarbazepine with Tolvaptan?
MediHelp rates the interaction as moderate. Oxcarbazepine and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce tolvaptan exposure by inducing CYP3A4, which can blunt its aquaretic effect. Inadequate response may leave hyponatremia undertreated.
How serious is the interaction between Oxcarbazepine and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and clinical response, and increase tolvaptan dose within labeled limits if needed. Note that oxcarbazepine itself can cause hyponatremia.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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