Drug interactions
Oxcarbazepine + Trabectedin
Severity: Moderate
Oxcarbazepine and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trabectedin is metabolized primarily by CYP3A4, and inducers may lower its exposure and reduce efficacy. Labeling advises avoiding strong inducers; oxcarbazepine is expected to have a smaller effect.
What this interaction means in plain words
Oxcarbazepine and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Trabectedin belongs to Oncology.
Why it happens
Oxcarbazepine induces CYP3A4, increasing trabectedin clearance.
What to do
Prefer a non-inducing antiseizure drug and monitor tumor response if the combination is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Trabectedin
Frequently asked questions
Can I take Oxcarbazepine with Trabectedin?
MediHelp rates the interaction as moderate. Oxcarbazepine and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trabectedin is metabolized primarily by CYP3A4, and inducers may lower its exposure and reduce efficacy. Labeling advises avoiding strong inducers; oxcarbazepine is expected to have a smaller effect.
How serious is the interaction between Oxcarbazepine and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure drug and monitor tumor response if the combination is needed.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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