Drug interactions
Oxcarbazepine + Zuranolone
Severity: Moderate
Oxcarbazepine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, dizziness and psychomotor impairment, and combined use may worsen these effects. Zuranolone labeling warns about additive effects with other CNS depressants. Oxcarbazepine may also reduce zuranolone levels through CYP3A4 induction.
What this interaction means in plain words
Oxcarbazepine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus possible CYP3A4 induction by oxcarbazepine lowering zuranolone exposure.
What to do
Counsel patients about drowsiness and driving impairment, and reduce the zuranolone dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Oxcarbazepine with Zuranolone?
MediHelp rates the interaction as moderate. Oxcarbazepine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, dizziness and psychomotor impairment, and combined use may worsen these effects. Zuranolone labeling warns about additive effects with other CNS depressants. Oxcarbazepine may also reduce zuranolone levels through CYP3A4 induction.
How serious is the interaction between Oxcarbazepine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and driving impairment, and reduce the zuranolone dose if excessive sedation occurs.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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