Drug interactions
Oxybutynin + Rufinamide
Severity: Minor
Oxybutynin and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and could slightly lower oxybutynin exposure. The effect is likely small, and both drugs can cause somnolence and dizziness.
What this interaction means in plain words
Oxybutynin and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxybutynin belongs to Genitourinary; Rufinamide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by rufinamide increasing oxybutynin metabolism.
What to do
No routine adjustment is needed; reassess bladder symptom control and monitor for additive drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Oxybutynin with Rufinamide?
MediHelp rates the interaction as minor. Oxybutynin and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and could slightly lower oxybutynin exposure. The effect is likely small, and both drugs can cause somnolence and dizziness.
How serious is the interaction between Oxybutynin and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess bladder symptom control and monitor for additive drowsiness.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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