Drug interactions
Oxybutynin + Scopolamine
Severity: Moderate
Oxybutynin and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic agents, so combining them increases dry mouth, constipation, urinary retention, blurred vision and CNS effects such as drowsiness and confusion. The burden is greatest in older adults, who may develop delirium.
What this interaction means in plain words
Oxybutynin and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Avoid the combination in older or cognitively impaired patients where possible. Otherwise monitor for anticholinergic toxicity and reduce the dose if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Oxybutynin
Frequently asked questions
Can I take Oxybutynin with Scopolamine?
MediHelp rates the interaction as moderate. Oxybutynin and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic agents, so combining them increases dry mouth, constipation, urinary retention, blurred vision and CNS effects such as drowsiness and confusion. The burden is greatest in older adults, who may develop delirium.
How serious is the interaction between Oxybutynin and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older or cognitively impaired patients where possible. Otherwise monitor for anticholinergic toxicity and reduce the dose if it occurs.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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