Drug interactions
Oxybutynin + Zuranolone
Severity: Moderate
Oxybutynin and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes significant sedation and impairs driving and psychomotor performance. Oxybutynin adds central anticholinergic effects such as drowsiness, dizziness and confusion, so impairment may be greater.
What this interaction means in plain words
Oxybutynin and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant and anticholinergic pharmacodynamic effects.
What to do
Monitor for excessive sedation and cognitive impairment, and consider reducing the zuranolone dose if symptoms occur. Warn patients not to drive or operate machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Oxybutynin with Zuranolone?
MediHelp rates the interaction as moderate. Oxybutynin and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes significant sedation and impairs driving and psychomotor performance. Oxybutynin adds central anticholinergic effects such as drowsiness, dizziness and confusion, so impairment may be greater.
How serious is the interaction between Oxybutynin and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and cognitive impairment, and consider reducing the zuranolone dose if symptoms occur. Warn patients not to drive or operate machinery.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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