Drug interactions
Oxymetholone + Warfarin
Severity: Major
Oxymetholone and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymetholone, an anabolic androgenic steroid, markedly enhances the anticoagulant effect of warfarin and can raise the INR rapidly. This increases the risk of serious bleeding.
What this interaction means in plain words
Oxymetholone and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Anabolic steroids reduce synthesis or increase catabolism of vitamin K-dependent clotting factors and may alter warfarin sensitivity, potentiating anticoagulation.
What to do
Avoid the combination where possible; if used, reduce the warfarin dose in advance and check INR frequently during and after oxymetholone therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Oxymetholone and Warfarin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Oxymetholone with Warfarin?
MediHelp rates the interaction as major. Oxymetholone and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxymetholone, an anabolic androgenic steroid, markedly enhances the anticoagulant effect of warfarin and can raise the INR rapidly. This increases the risk of serious bleeding.
How serious is the interaction between Oxymetholone and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, reduce the warfarin dose in advance and check INR frequently during and after oxymetholone therapy.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
