Drug interactions
Oxymorphone + Phendimetrazine
Severity: Minor
Oxymorphone and Phendimetrazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a stimulant anorectic, and its stimulant effect may partly offset opioid sedation without lessening respiratory depression. The overall clinical effect is unpredictable, and the stimulant may mask sedation.
What this interaction means in plain words
Oxymorphone and Phendimetrazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS pharmacodynamic effects; there is no established pharmacokinetic interaction.
What to do
Monitor the patient's response and do not rely on stimulant alertness as a sign that opioid effects are absent.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Oxymorphone with Phendimetrazine?
MediHelp rates the interaction as minor. Oxymorphone and Phendimetrazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phendimetrazine is a stimulant anorectic, and its stimulant effect may partly offset opioid sedation without lessening respiratory depression. The overall clinical effect is unpredictable, and the stimulant may mask sedation.
How serious is the interaction between Oxymorphone and Phendimetrazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the patient's response and do not rely on stimulant alertness as a sign that opioid effects are absent.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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