Drug interactions
Oxymorphone + Pimozide
Severity: Moderate
Oxymorphone and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide is sedating and combined with oxymorphone may increase drowsiness, hypotension and respiratory depression. Dose-related effects are most likely in opioid-naive or frail patients.
What this interaction means in plain words
Oxymorphone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of an antipsychotic and an opioid.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially during initiation and dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Oxymorphone with Pimozide?
MediHelp rates the interaction as moderate. Oxymorphone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide is sedating and combined with oxymorphone may increase drowsiness, hypotension and respiratory depression. Dose-related effects are most likely in opioid-naive or frail patients.
How serious is the interaction between Oxymorphone and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially during initiation and dose changes.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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