Drug interactions
Oxymorphone + Protriptyline
Severity: Moderate
Oxymorphone and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants combined with opioids can increase sedation and respiratory depression. Protriptyline is less sedating than other tricyclics, but additive effects, anticholinergic effects and constipation remain possible.
What this interaction means in plain words
Oxymorphone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for sedation, respiratory depression, urinary retention and constipation, and reduce doses if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Oxymorphone with Protriptyline?
MediHelp rates the interaction as moderate. Oxymorphone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants combined with opioids can increase sedation and respiratory depression. Protriptyline is less sedating than other tricyclics, but additive effects, anticholinergic effects and constipation remain possible.
How serious is the interaction between Oxymorphone and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression, urinary retention and constipation, and reduce doses if these occur.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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