Drug interactions
Oxymorphone + Quazepam
Severity: Major
Oxymorphone and Quazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines used with opioids carry a boxed warning for profound sedation, respiratory depression, coma and death. Quazepam has long-acting active metabolites, so the risk persists for days.
What this interaction means in plain words
Oxymorphone and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid receptors and enhanced GABA-A activity.
What to do
Avoid the combination unless alternatives are inadequate; if it is used, limit doses and duration and monitor sedation and respiration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Oxymorphone with Quazepam?
MediHelp rates the interaction as major. Oxymorphone and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines used with opioids carry a boxed warning for profound sedation, respiratory depression, coma and death. Quazepam has long-acting active metabolites, so the risk persists for days.
How serious is the interaction between Oxymorphone and Quazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless alternatives are inadequate; if it is used, limit doses and duration and monitor sedation and respiration.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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