Drug interactions
Oxymorphone + Remimazolam
Severity: Major
Oxymorphone and Remimazolam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam given with opioids can result in deeper sedation, respiratory depression and hypotension than either alone. Serious outcomes including death are possible without appropriate monitoring.
What this interaction means in plain words
Oxymorphone and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxymorphone belongs to Musculoskeletal; Remimazolam belongs to Central Nervous System.
Why it happens
Synergistic CNS and respiratory depression via GABA-A potentiation and opioid receptor agonism.
What to do
Titrate remimazolam carefully, often at reduced doses, and monitor vital signs and oxygenation continuously through recovery. Have airway support and reversal agents available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Oxymorphone with Remimazolam?
MediHelp rates the interaction as major. Oxymorphone and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Remimazolam given with opioids can result in deeper sedation, respiratory depression and hypotension than either alone. Serious outcomes including death are possible without appropriate monitoring.
How serious is the interaction between Oxymorphone and Remimazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully, often at reduced doses, and monitor vital signs and oxygenation continuously through recovery. Have airway support and reversal agents available.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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