Drug interactions
Oxymorphone + Sage
Severity: Minor
Oxymorphone and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some sage preparations may have mild sedative effects, so additive drowsiness with oxymorphone is theoretically possible. Evidence is lacking and the effect is likely small.
What this interaction means in plain words
Oxymorphone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the mechanism is theoretical and not well established.
What to do
Counsel patients to report excess sedation when taking sage supplements with oxymorphone. No routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Oxymorphone with Sage?
MediHelp rates the interaction as minor. Oxymorphone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some sage preparations may have mild sedative effects, so additive drowsiness with oxymorphone is theoretically possible. Evidence is lacking and the effect is likely small.
How serious is the interaction between Oxymorphone and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report excess sedation when taking sage supplements with oxymorphone. No routine dose change is required.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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