Drug interactions
Oxymorphone + Thiothixene
Severity: Moderate
Oxymorphone and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics with sedative properties add to opioid CNS depression and may also cause hypotension. The result may be excessive drowsiness, impaired cognition and reduced respiratory drive.
What this interaction means in plain words
Oxymorphone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with alpha-adrenergic and antihistaminic effects contributing to sedation and hypotension.
What to do
Monitor sedation and blood pressure, and consider lower starting doses of oxymorphone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Oxymorphone with Thiothixene?
MediHelp rates the interaction as moderate. Oxymorphone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics with sedative properties add to opioid CNS depression and may also cause hypotension. The result may be excessive drowsiness, impaired cognition and reduced respiratory drive.
How serious is the interaction between Oxymorphone and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and consider lower starting doses of oxymorphone.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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