Drug interactions
Oxymorphone + Topiramate
Severity: Moderate
Oxymorphone and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate can cause drowsiness, cognitive slowing and dizziness, which add to the sedation produced by oxymorphone. Impaired alertness and psychomotor function may be more pronounced than with either drug alone.
What this interaction means in plain words
Oxymorphone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergism.
What to do
Monitor for excessive sedation, confusion and respiratory depression, particularly when starting or increasing either drug. Counsel patients to avoid driving and other hazardous tasks until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Oxymorphone and Topiramate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Topiramate
Frequently asked questions
Can I take Oxymorphone with Topiramate?
MediHelp rates the interaction as moderate. Oxymorphone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topiramate can cause drowsiness, cognitive slowing and dizziness, which add to the sedation produced by oxymorphone. Impaired alertness and psychomotor function may be more pronounced than with either drug alone.
How serious is the interaction between Oxymorphone and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, confusion and respiratory depression, particularly when starting or increasing either drug. Counsel patients to avoid driving and other hazardous tasks until the response is known.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
