Drug interactions
Oxymorphone + Trifluoperazine
Severity: Moderate
Oxymorphone and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines taken with opioids can increase sedation, hypotension and respiratory depression. The effect is usually manageable but can be significant in the elderly or at high doses.
What this interaction means in plain words
Oxymorphone and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with alpha-adrenergic blockade contributing to hypotension.
What to do
Monitor sedation, blood pressure and respiratory status, and reduce the oxymorphone dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Oxymorphone with Trifluoperazine?
MediHelp rates the interaction as moderate. Oxymorphone and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines taken with opioids can increase sedation, hypotension and respiratory depression. The effect is usually manageable but can be significant in the elderly or at high doses.
How serious is the interaction between Oxymorphone and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and respiratory status, and reduce the oxymorphone dose if excessive sedation occurs.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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