Drug interactions
Oxymorphone + Triprolidine
Severity: Moderate
Oxymorphone and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a sedating antihistamine with oxymorphone increases drowsiness and may add to respiratory depression. Oxymorphone labeling advises caution with other CNS depressants.
What this interaction means in plain words
Oxymorphone and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS and respiratory depression from H1 antagonism and mu-opioid agonism.
What to do
Monitor sedation and respiratory rate, particularly at initiation or dose increases. Use a non-sedating antihistamine if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Oxymorphone with Triprolidine?
MediHelp rates the interaction as moderate. Oxymorphone and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a sedating antihistamine with oxymorphone increases drowsiness and may add to respiratory depression. Oxymorphone labeling advises caution with other CNS depressants.
How serious is the interaction between Oxymorphone and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, particularly at initiation or dose increases. Use a non-sedating antihistamine if possible.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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