Drug interactions
Oxymorphone + Valerian
Severity: Moderate
Oxymorphone and Valerian: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has sedative properties that may add to the CNS depression produced by oxymorphone. This may increase drowsiness, impaired psychomotor performance and, rarely, respiratory depression.
What this interaction means in plain words
Oxymorphone and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedation, probably via GABAergic activity of valerian constituents; evidence is limited.
What to do
Advise patients to avoid valerian while taking oxymorphone or to use it only with careful monitoring for excess sedation. Counsel against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Oxymorphone with Valerian?
MediHelp rates the interaction as moderate. Oxymorphone and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valerian has sedative properties that may add to the CNS depression produced by oxymorphone. This may increase drowsiness, impaired psychomotor performance and, rarely, respiratory depression.
How serious is the interaction between Oxymorphone and Valerian?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid valerian while taking oxymorphone or to use it only with careful monitoring for excess sedation. Counsel against driving and alcohol use.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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