Drug interactions
Oxymorphone + Zotepine
Severity: Moderate
Oxymorphone and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine is a sedating antipsychotic, and combining it with an opioid such as oxymorphone increases the risk of drowsiness, hypotension and respiratory depression. Zotepine also lowers the seizure threshold and may prolong the QT interval.
What this interaction means in plain words
Oxymorphone and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from mu-opioid agonism and antagonism of histaminergic, alpha-adrenergic and other receptors by zotepine.
What to do
Start with the lowest effective doses and monitor sedation, blood pressure and respiratory rate. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Oxymorphone with Zotepine?
MediHelp rates the interaction as moderate. Oxymorphone and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine is a sedating antipsychotic, and combining it with an opioid such as oxymorphone increases the risk of drowsiness, hypotension and respiratory depression. Zotepine also lowers the seizure threshold and may prolong the QT interval.
How serious is the interaction between Oxymorphone and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and monitor sedation, blood pressure and respiratory rate. Advise patients to avoid driving and alcohol.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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